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The collection includes manuscript materials (correspondence, land warrant, accounts, receipts, petition and will) and printed and typescript materials (invitations, broadside, newspaper and magazine clippings). Subjects of the various items include sale and survey of land; schools, churches, estates, comment on and description of agriculture, social and economic conditions in Kentucky, Georgia, Louisiana, South Carolina, Missouri, Illinois, Iowa, California, Morgantown, Fairmont, and Wheeling, WV, and Ireland; westward migration [1849]; gold mining, enslaved Africans; and business and family affairs.

The collection includes 57 letters (1795-1871) to or from Benjamin H., Henry, James G., James O., Rebecca D., and Thomas Watson; 3 land grants on sheep-skin (1787-1798) Monongalia County; 25 articles of agreement (1812-1875), manuscript; 4 manuscript wills or copies of wills (1852-1862); 32 surveys, maps, and plats of coal fields (1798-1892); 99 tax receipts (1807-1865), manuscript and printed forms; 44 receipts for clerking fees (1815-1845) manuscript and printed forms; 79 receipts, bills, notes (1782-1862), manuscript and printed forms; 51 miscellaneous manuscript and printed forms (1790-1902), including inventories of estates, sale bills, notes on legal matters with respect to property, court proceedings, etc.; and one manuscript constable's receipt book of Campbell and Watson.

The collection contains 41 manuscripts dating 1770-1831. Many of the manuscripts date from the era of the American Revolution, and several are directly relevant to the course of the war. Among the documents are single letters by John Adams, Aaron Burr, Benjamin Franklin, Alexander Hamilton, John Hancock, Patrick Henry, John Jay, Thomas Jefferson, Lafayette, James Madison, John Marshall, James Monroe, Paul Revere, and George Washington, as well as letters and other documents that include the signatures of signers of the Declaration of Independence.

Account books of several generations of the Welch family of Fauquier County, Virginia. The earliest book includes notes, 1767-1778, of Thomas Glascock. The early volumes were probably kept by or for Sylvester Welch (1764-1832), the later ones by or for Sylvester Welch (b. 1800).

This collection is primarily general family correspondence including Civil War letters (dated 1862-1864) from John P. Welsh, a Confederate infantry officer, and James L. Welsh. There are also 34 family letters on microfilm, 12 of which were written by John P. Welsh during his confinement in a Federal prison.

Collection of class photographs from a number of departments within the Health Sciences Center (HSC), in addition to materials covering the 2010 HSC 50th anniversary and materials from the forming of the Health Sciences Library as well as miscellaneous materials relating to or collected by Alderson Fry, the first Medical Librarian at West Virginia University (1954).