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This collection predominantly contains the personal papers of William Gregory, including: journals, notebooks, property records, deeds, and family records. Approximately two-thirds of the collection comprise original correspondence, and late 20th century transcriptions of such.

Business letters, 1833-1839, to Major William K. Perrin and 1855, 1860, to his son-in-law Wyndham Kemp, both of Gloucester County, Virginia from Perrin's step-son Robert W. Nicolson in Uniontown, Perry County, Alabama, about the management of a cotton plantation. Letters mention purchasing land, growing and selling cotton, and the management of the enslaved, legal and banking matters and uprising of the Creek Indians. Papers, 1800-1855 and undated, relating to the hiring out and management of enslaved persons in Gloucester County, Virginia by William K. Perrin. Legal papers, 1723-1895 and undated, include indentures, agreements, and lists of debts of William K. Perrin, George D. Nicolson, Sarah T. Nicolson, and descendants of William K. Perrin. Also accounts and receipts, 1806-1902, and undated.

Papers, 1783-1837, of William Langborn and concerning his estate which was administered by Burwell Bassett. Includes letters, 1793-1805, from William Murdock, agent for Langborn in London, Eng. and typescripts of letters, 1790-1791, from William Langborn to William Short; and abstract from the correspondence of William Short concerning Langborn. Subjects discussed by Murdock include Jay's Treaty; and Langborn's rental houses in London.