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A scrapbook and clippings, advertisements, letters, manuscripts of speeches, and notes on medical practice, compiled by Dr. John Frissell (1810-1882), a physician at the Wheeling Hospital and medical superintendent of military prisoners and soldiers in Wheeling during the Civil War. The scrapbook is a folio volume, Register of the Sick and Wounded, U.S.A. General Hospital. There is also information on the Medical Society of the City of Wheeling, the West Virginia Medical Society, medical conventions in West Virginia, and Wheeling local history.

Papers of Dr. Margaret Byrnside Ballard (1900-1991), regarding the history of Monroe County, West Virginia, and the Ballard family. As a genealogist and author of local history, she was an avid collector of the historical materials contained in this collection, most of which relate to her family and Monroe County. The collection includes personal papers, business records, historical and genealogical research material, scrapbooks, bibles, memorabilia, artifacts, photographs, broadsides, paintings, and postage stamps. See the Historical Note for more information about Dr. Ballard.

Daybooks for the practice of Dr. Marmaduke Dent (1801-1880), a physician in Monongalia County, and for a general store in Granville.

Personal, medical, and business papers, account books, and daily journals of a Harpers Ferry physician (d. 1883). Subjects include the practice of a small town doctor, his related business interests, and the education and careers of his children, three of whom became medical doctors. Included are the papers of William V. Marmion (1840-1922), who studied eye surgery in Vienna and established a practice in Washington, D.C. There are letters from George Marmion, acting surgeon and secretary of the National Home for Disabled Volunteer Soldiers, and letters of Robert A. Marmion (1844-1907), who was a naval surgeon and the first president of the Naval Medical School in Washington, D.C. Many of the letters, especially after 1883, are those of the Marmion heirs and are concerned with family, personal, and financial affairs. Some letters shed light on the condition of the gold market after the Civil War and family activities as prominent members of the Roman Catholic faith. There are a few fragmentary records regarding John Hancock Hall, a relative, who invented and patented the first American breechloading rifle in 1811. He was later hired by the government in 1819 to establish and operate a "rifle works" in close proximity to the federal armory at Harpers Ferry (see box 17).

Official transcript of a civil suit which originated in 1829 when John Wishart rendered medical treatment to David White, and White failed to pay for the services. Wishart sued in Ohio Co. Court, and the case was resolved in 1832.

Correspondence, business papers, and an account book of Peter T. Laishley, a Methodist minister, physician, and merchant in Monongalia County. There are papers on the settlement of the estate of Richard Laishley in England, marriages performed by Laishley; Laishley family birth and marriage notes; accounts for services as a minister and physician, 1833-1839; and other items on church and local history.

Papers of the Rush Dew Holt family relating to Matthew S. Holt, Andrew E. Holt, Ralph K. Chase, and Helen Jane (Holt) Seale. The collection includes correspondence, publications, photographs, and clippings, among other material that documents the personal and business activities of the Holt family. The collection is divided into five series as follows: Dr. Matthew S. Holt Papers (1837-1943), Andrew E. Holt Papers (1926-1958), Ralph K. Chase Papers (1918-1947), Helen Jane Holt Seale Papers (ca. 1930-2008), and Mixed (ca. 1820-2013 and undated).

A physician's account book with index, 1869-1887, for a practice in Mason County, West Virginia, and Pomeroy, Ohio; and a folder of loose invoices for household accounts, building supplies, groceries, harness and leather goods, and clothes.