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This collection contains items of the Anderson and Alexander families including correspondence dealing with legal business, family matters, and Lexington, Virginia affairs. Consists largely of the family correspondence of William Alexander Anderson, Francis T. Anderson, and Mary Anne Alexander Anderson; includes letters to and from Virginia Governor John Letcher, and two letters from Mildred Lee, daughter of Robert E. Lee. Other correspondents include William A. Glasgow, George Hutcheson Denny, Charles Alfred Graves, Henry Holstine, George Junkin, George Bolling Lee, William Henry Fitzhugh Lee, James McDowell, Samuel McDowell Moore, and Walter LeConte Stevens. Also includes legal and business correspondence of Francis T. Anderson; letters and diary of William D. Alexander dated 1858-1859; business accounts, wills, obituaries, including Mary Anne Alexander Anderson's obituary as a pamphlet titled In Memoriam, November 27, 1881; and genealogies of the McNutt, Anderson, and Thomas families. Includes copies of speeches of William A. Anderson dated 1842-1930 and a few photographs.

Letters, accounts, and legal papers of Dr. Charles Brown. Collection includes letters, 1813-1818, concerning patients (including slaves).

This collection of historic manuscripts dates from 1607-1933, with the bulk of materials dating from 1738-1868. The correspondence, journals and diaries, legal and financial records, estate documents, and printed ephemera in the collection primarily relate to the Washington and Custis families, the Revolutionary War, and society life in antebellum Washington D.C. and Virginia.

This collection contains the family and personal correspondence (1806-1897), business correspondence, deeds, legal papers, account books (1849-1862) of Dr. Alexander S. Dillon (1813-1870), and family Bible along with ledgers and employee time books of various Dillon limestone companies, especially Edward Dillon and Co. in Botetourt County. Correspondents include Dr. Alexander S. Dillon (1813-1870), Edward Dillon (1835-1897), Edward Davis Dillon (1766-1818), Fanny Polk Dillon, and Patrick Henry Dillon (1804-1862).

This collection includes correspondence concerning Campbell's negotations (1824-1825) as commissioner to the Creek Indians; a transcript of the proceedings and subsequent treaty of agreement relating to the removal of the Indians to points west of the Mississippi River; land deed of Archibald Campbell (d. 1820); and Campbell family genealogy.