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Correspondence, legal and business papers, mercantile records and tax receipt books of Isaac McNeel, who operated a store at Edray and Mill Point, Pocahontas County, West Virginia, served as sheriff of the county, operated a gristmill, raised livestock, and was appointed provost marshal of the county in 1862 by the Confederate Army. The collection also includes letters and school reports of McNeel's sons, Winters and Summers, while students at Washington and Lee and the Medical and Law Departments of the University of Virginia, 1893-1897. Other school material pertains to the Hillsboro Male and Female Academy and the Lewisburg Female Institute. Subjects include mercantile and cattle trade with Baltimore and Richmond; business conditions in the l850s and in Richmond during the Civil War; slave hiring; ginseng trade; agriculture; the American Party, 1855; Henry A. Wise; Virginia Secession Convention; effect of the Union blockade on Richmond commerce; speculation in whiskey, tobacco, and cattle during the Civil War; and postwar economic and political conditions in the Pocahontas County area.

Papers of a livestock broker, farmer, and merchant of Mingo Flats, Randolph County, who was associated with John T. McGraw in the development of Marlinton and the purchase and sale of land, coal, and timber in neighboring Pocahontas County. There are some items of Civil War interest, while the bulk of the correspondence relates to the marketing of ginseng, beeswax, wool, venison, animal pelts, and farm machinery. There is significant correspondence relating to state politics and railroads. Correspondents include J.M. Bennett, J.N. Camden, David Goff, John J. Jackson, McCormick Harvesting Machine Company, John T. McGraw, and The Pocahontas Development Company. Also includes some material of G.E. Jarvis, father of Anna Jarvis, the founder of Mother's Day.

Letter and account books, clipping scrapbooks, and miscellaneous family papers of a pioneer, Ohio Valley, general merchandise firm founded by Dudley Woodbridge, Sr., at Marietta, Ohio, and operating under various names for a period of more than sixty years. The collection also includes the account books of Daniel, Richard, and John Greene, 1808-1844; account books of F.B. Loomis, 1842-1844; a medicinal formulary book; the estate records of John Brody; records of a pension and bounty land claims agency operated by George M. Woodbridge, 1861-1864; and justice of the peace accounts, 1832-1863. Subjects include the development of river markets, transportation, and the livestock industry in the early Ohio Valley; fur trade and commerce with England and Europe; the Marietta and Susquehanna Trading Company; Kanawha and Sciota salt works; Ohio Company lands; Woodbridge-Harman Blennerhassett partnership; ginseng trade; Wheeling Cotton Manufacturing Company; ropewalk and shipbuilding in Marietta; military land warrants; estate of George Morgan; career of William Woodbridge, United States senator and governor of Michigan; pioneer education; Meadville Seminary; Ohio University; Miami University; Marietta Collegiate Institute; Belpre, Ohio; American Catholic missions; early history of Marietta; the American Colonization Society; Washington County Colonization Society; churches; Washington County Tract Society; recruiting in Marietta during the Civil War; impact of the War of 1812 on westward migration and labor; and Woodbridge family affairs. Letters are addressed to merchants in London, France, New York, Philadelphia, Pittsburgh, Charleston (West Virginia), Lexington and Louisville (Kentucky), Cincinnati, St. Louis, New Orleans, Washington, Detroit, and Baltimore. Correspondents include Lewis Cass, Philip Doddridge, and Benjamin Reeder.