- John T. Parsons Papers, 1910/200011,295
- Rick Boucher Papers, 1968/2017, bulk 1975/20116,327
- Fries Textile Plant Records, 1900/19885,424
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19695,394
- M. Rupert Cutler Papers, 1930/2021, bulk 1962/20214,187
- Records of the Office of the President, Julian A. Burruss, 1906/19462,950
- Records of the Office of the President, T. Marshall Hahn, Jr., 1962/19742,935
- Records of the Office of the Vice President for Administration, Stuart K. Cassell, 1945/19752,499
- Pocahontas Mines Collection, 1883/19972,405
- Robert E. Marshak Papers, 1933/19952,204
- Samuel Herrick Papers, 1930/19742,167
- Farrier Family Papers, 1894/19721,946
- Smithey & Boynton, Architects & Engineers Records, 1922/19851,818
- Virginia Academy of Science Records, 1920/20051,809
- Records of the Office of Academic Affairs, Leslie F. Malpass, Alfred Krebs, and Donald C. Darnton, 1961/1977, bulk 1965/19761,752