- Samuel G. Clark Liberty Iron Furnace Collection, 1809/1917482
- Sara Borden Collection, 1914/198310
- Shenandoah County Aerial Photograph Collection, 1989/200096
- Shenandoah County Historical Society Collection, 1147/2000141
- Shenandoah County Library System Collection, 1911/2017164
- Shenandoah County Tourism Collection, 1940/201540
- Shenandoah Valley Equality Collection, 2002/20221
- Sherrie Miller Collection, 1900/196371
- Spiggle Family Collection, 1818/19559
- Spitzer Family Collection, 1912/195953
- St. Mark's Lutheran Church Collection, 1851/2024163
- St. Peters Lutheran Church Collection, 1905/200328
- Strasburg Ephemera Collection, 1900/19159
- Strasburg Library Collection, 1838/200511
- Susan Sanderlin Collection, 1861/194197