- Acker Family Diaries, 1880/19061
- Bowman Family Papers, 1765/19981
- Brocks Gap photographs, 19151
- Charles T. Smith photographs, 1880/2007, bulk 1990/19991
- Charles Triplett O'Ferrall papers, 1870/18931
- Cross Keys Precinct voting records, 1902/19601
- Drugs in the valley: fifty years of Merck and Co. oral history collection, 19901
- Dudley and Rexrode Family Papers, 1873/20051
- Eldon Bowman collection of Bowman family papers, 1797/20191
- Elizabeth "Libby" Custer Papers, 1930/19971
- Ezra M. Minnick Sr. diary, 19001
- George E. May Papers, 1930/19391
- George E. Whitesel papers on Golden Scotch Collie breeding, 1940/19461
- George K. Harnsberger Ledger, 1939/19571
- George W. Kemper Jr. Medical Ledger, 1857/1892, bulk 1861/18681