- An Historical Map of Roanoke County, Virginia (from The Roanoke Times), 19681
- Arthur W. Grove Family Papers,, 1900/19571
- Blacksburg, Virginia, Bank Embezzlement Collection, 18651
- Business Section, City of Roanoke, 19501
- Carbon Coal Corporation Embosser, 19171
- Charlotte D. Gale Photograph Album, 1898/19001
- Fay M. Thomas Letters to Edward L. Stone, 19311
- Granville Skidmore Kennedy Family Papers, 1935/19721
- Harry Baker Cawley Collection, 1918/19261
- Hidden History: The Black Experience in the Roanoke Valley Cassette Tapes and Transcripts, 19921
- Hotel Roanoke Menus, 1942/19931
- John Garst Account Ledgers, 1844/18501
- Joseph B. Mills Log Book, 1908/19091
- Letter to Ruth H. Shootman, 18461
- M. Rupert Cutler Papers, 1930/2021, bulk 1962/20211