- Albert H. Toothman, Author and Compiler, 'My Wetzel Connection', 20071
- Arthurdale Homestead Project Clippings, 1934/19771
- Arthurdale, West Virginia Scrapbooks, 1935/19751
- Ashford Brown Papers, Archives, 1831/18431
- Aurora, Preston County Papers, 1754/19001
- Benjamin Trembly, Deed for Sale of Land in Preston County, West Virginia, 1812/18131
- Bowman Collection Papers, 1885/19061
- Brown and Parsons Families Papers, 1846/19601
- Carleton Custer Pierce (1877-1958) Papers, 1840/19551
- Charles Mortimer Bishop (1827-1896) Papers, 1857/18971
- Charles N. Brown Medical Journal, 1894/19051
- Christina Matheny, Collector, Hibbs Family Papers, 1855/18791
- Clyde Cale, Collector, Photographs of Preston County Schools, Students, and Teachers, 1907/19161
- Coal Mining Disaster Reports Collection, 1938/19771
- County Highway Maps for West Virginia, 19371