- A.S. Hammack papers, 1864/19541
- Abraham's Table manuscript, 1983/20122
- Additional Papers of Charles Wright
1957-20033
- Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/19702
- Allan Blank Papers, 1958/200910
- Alumni Association Records, 1924/20161
- American Association of University Women (AAUW) Records, Harrisonburg, Virginia Branch, 1929/20251
- Andrew Kohen papers, 1977/20061
- Arthur J. Morris memorabilia, 1884/19921
- Athletics, 1830/202534
- Audrey Emmons Architectural Collection, 1974/19975
- Bailey-Law Collection, 1825/19714
- Baldwin Family Letters, 1861/18971
- Black Studies, Black Spaces oral histories, 20195
- Black Women at Virginia Tech Oral History Project Records, 1967/2000, bulk 1994/200015