- Cook Family Papers, 1872/197712
- Cultural Alliance of Greater Hampton Roads Records, 1972/20184
- David P. Neff Papers, 1954/19902
- Dean of the College of Arts and Letters Records, 1963/20223
- Dean of the Darden College of Education and Professional Studies Records, 1962/2018, bulk 1962/19802
- Dean of the School of Business Administration Records, 1959/19778
- Dean of the School of Sciences and Health Professions Records, 1964/19805
- Department of English Records, 1934/19902
- Department of Women's Studies Records, 1973/20233
- Desegregation of Virginia Education (DOVE) Collection, 1958/20123
- Dorothy M. Jones Papers, 1954/19835
- Doughty Family Papers, 1855/19045
- Edith R. White Papers, 1923/20104
- Edward G. Carson Papers, 1924/2004, bulk 1970/20003
- Edward L. Schrock Papers, 1999/20045