- Hugh Adams papers, 1857/18601
- Intercollegiate Athletics Records, 1930/2023, bulk 1975/20001
- Internal Library Records, 1923/202319
- Kelvin Ramsey Collection of Stereoviews Test, 1900/200011
- Lester Babcoke Collection, 1959/19821
- Mary Jo Sweeney Collection, 1829-19483
- Mason C. Andrews Papers, 1777/2010, bulk 1950/19902
- Meridian Institute / Health and Rejuvenation Research Center
Collection, 1989-201513
- Methodist Files, 1784/20242
- Papers of Ambrose Bierce, 1842-19141
- Paul G. Caplan Papers, 1890/20042
- Record Group Vertical Files51
- Records of the Virginia Tech University Libraries, 1925/20061
- Richard J. DeMartino papers, 1910/19651
- Robert Adriance Collection, 1949-20022