- Chapman Family Collection (MS274), 1828/196310
- Chapman-Southerland Collection (MS409), 1878/19135
- Charles L. Sampson Collection (MS126), 1841/198668
- Civitan and Civinette Clubs of Alexandria Collection (MS038), 1942/197810
- Curtin Family Papers (MS101), 1885/200017
- Daniel O'Sullivan Collection (MS141), 1850/191210
- Delos H. Smith Collection (MS307), 1900/19508
- Dickman Collection (MS069), 1968/19859
- Early Building and Repair Permits (MS040), 1890/194981
- Edith Moore Sprouse Papers (MS313), 1960/200399
- Elanora Peake Zint Collection (MS345), 1924/200642
- Eleanor Lee Templeman Collection (MS061), 1810/1990308
- Elrich W. Murphy Photograph Collection (MS415), 1940/196951
- Esther Holliday Green Collection (MS073), 1859/198268
- Ethelyn Cox Collection (MS287), 1956/1980519