- Abraham Grove Account Book, 1815/18501
- Amos Koontz Papers I, 1809/1965, bulk 1936/19651
- Annie Baker Tucker's Colonial Ancestral Chart and Family Records, 1888/19191
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Benjamin Stoddert Ewell Papers, 1784/1934, bulk 1830/18921
- Bevill Family Papers, 1558/1939, bulk 1558/17071
- Broome Family Papers, 1862/19951
- Cabell Family Homes and Graveyards Collection, 2008/20121
- Caroline Baytop Sinclair Papers, 1938-1993, 1938/19931
- Chappelear Collection, 1788/19591
- Charles Campbell Papers, 1743/18961
- Cook Family Papers, 1872/19771
- Doughty Family Papers, 1855/19041
- Earl Gregg Swem Genealogy Collection, 1719/19821
- Fay Parr Papers, 1920/20021