- Sally H. Thomas papers77
- Samuel Price, Lawyer and Politician, Papers6
- Samuel Vaughan Wilson Papers219
- Samy Elias, Engineering Professor, Personal Rapid Transit Records24
- Sheet Music Collection8
- Siler Family Papers56
- Smithey & Boynton, Architects & Engineers Records1
- Smithfield Plantation House Architectural Drawings,2
- Soil Conservation Society of America, West Virginia Chapter, Records2
- Somerville family papers23
- Stewart Plein, Librarian and Collector, Papers1
- Storer College Administrative and Operational Records204
- Strother Family Papers5
- Stuart Family Papers1
- Summers County (W. Va.) Court Records and Miscellaneous Papers85