- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/187596
- Emory L. Kemp Papers regarding Industrial History, 1735/202110
- Ethel Fike Friend, Teacher, Papers, 1884/1993, bulk 1937/19937
- Ewell Snuffer, Mine Foreman and Inspector, Diaries, 1955/19975
- Faris, Faris, and Stephens, Architects, Records, 1890/2013226
- Farrier Family Papers, 1894/197244
- Fayette County (W. Va.) Court Records and Miscellaneous Papers, 1787/1923, bulk 1870/192330
- Festus P. Summers (1895-1971), Historian, Personal Diaries, 1953/19714
- Forbes, Anderson, and Hildebrand Families, Correspondence and Other Material, 1862/20134
- Foulke Family Papers, 1784/19141
- Frances Yeend, Opera Singer, Photographs, Recordings, and Papers, 1900/1990, bulk 1938/196642
- Francis H. Fife papers, 1785/2015, bulk 1940/201547
- Francis Harrison Pierpont Artifacts Collected by Jack Sandy Anderson, 1830/187610
- Frank (Tico) Herrera, Photographer, Photographic Negatives, Prints, and Other Material, 1960/20217
- Frank Gardiner Wisner papers, 1909/199720