- Clement Dixon Johnston Papers,, 1939/1979, bulk 1942/196223
- Cline M. Koon, Compiler, Koon Family Records, 1966/19744
- College of Agriculture and Life Sciences (CALS) Collection,, 1900/20014
- Dan H. Pletta Papers, 1942/199616
- David H. Sutton, Compiler, Research Papers regarding Helvetia, West Virginia, 1835/2010, bulk 1890/19793
- David Weimer, Collector, Seneca and Houze Glass Records, 1900/200519
- Davis & Davis Law Firm Records, 1895/191321
- Davis Coal and Coke, Coal Mining and Railroad Company, Records, 1890/198028
- Dolores Fleming, Research Papers regarding the Glass Industry, South Park Homes, and Other Topics, 1896/20163
- Don Knotts, Actor, Scripts, Sound Recordings, and Other Material, 1946/2006, bulk 1966/200011
- Dr. William A. Neal Papers, 1880/201610
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Earl W. Kennedy, Mine Inspector, Coal Company Mine Inspection Records, 1974/20138
- Early Records of the Mount Vernon Ladies' Association, 1853/1951, bulk 1853/187596
- Emory L. Kemp Papers regarding Industrial History, 1735/202110