- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20004
- Carl George Krieger Papers, 1930/196814
- Clement Dixon Johnston Papers,, 1939/1979, bulk 1942/196223
- College of Agriculture and Life Sciences (CALS) Collection,, 1900/20014
- Dan H. Pletta Papers, 1942/199616
- Earl Palmer Appalachian Photograph and Artifact Collection, 1880/19891
- Farrier Family Papers, 1894/197244
- Glass Lantern Slide Collection2
- Harry Downing Temple, Jr., Papers, 1872/2004, bulk 1930/20011
- Herbert Deuel Civil War Collection, 1864/18661
- J. Bolton McBryde Collection2
- John A. N. Lee Papers, 1973/199020
- John W. Landis Papers, 1949/196947
- Kathleen Cruise Architectural Papers, 1964/19958
- Lyric Theatre Collection, 1922/2006, bulk 1922/19794