- Sallie Bennett Papers regarding World War I Flying Ace Louis Bennett, Jr.1
- Sally H. Thomas papers59
- Sally Jane Brown, Artist, Collection6
- Sally Waldner Bould Stan Architectural Collection1
- Sam McColloch, Compiler, Three Manuscripts regarding Family History, Artists, and Fighter Pilot1
- Sam Sadler papers15
- Samuel F. Harsh Family, Genealogy, Photographs, and Artifacts1
- Samuel Spencer Stone, Compiler, Stone Family Papers1
- Samuel Vaughan Wilson Papers92
- Sanborn Insurance Atlas, Williamsburg, Virginia Collection1
- Sarah Pillsbury Harkness Architectural Collection2
- Schola Cantorum Records11
- School of Architecture student records from Professor Michael Bednar courses5
- School of Arts and Sciences Records 1926-[ongoing]5
- School of Business records13