- Sallie Bennett Papers regarding World War I Flying Ace Louis Bennett, Jr., 1873/2009, bulk 1904/19261
- Sally H. Thomas papers, 1968/201059
- Sally Jane Brown, Artist, Collection, 1959/2023, bulk 2013/20206
- Sally Waldner Bould Stan Architectural Collection, 1940/19971
- Sam Huff, West Virginia University and National Football League Football Player, Papers, 1930/2019, bulk 1955/20101
- Sam McColloch, Compiler, Three Manuscripts regarding Family History, Artists, and Fighter Pilot, 1904/20141
- Sam Sadler papers, 1960/200815
- Samuel F. Harsh Family, Genealogy, Photographs, and Artifacts, 1860/2011, bulk 1860/19101
- Samuel Spencer Stone, Compiler, Stone Family Papers, 1870/19981
- Samuel Vaughan Wilson Papers, 1945/201792
- Sanborn Insurance Atlas, Williamsburg, Virginia Collection, 1930/2007, bulk 1930/19601
- Sarah Pillsbury Harkness Architectural Collection, 1986/20132
- Schola Cantorum Records, 1995/201611
- School of Architecture student records from Professor Michael Bednar courses, 1972/20115
- School of Business records, 1929/202213