- Carol Barton papers, 1973/202023
- Charles T. Smith photographs, 1880/2007, bulk 1990/199929
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20007
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281
- College of Integrated Science and Technology (CISAT) records, 1987/200447
- Common Ground Records, 1983/20036
- Delta Sigma Theta Sorority, Inc. Iota Alpha Chapter 50th anniversary collection, 1973/20183
- Dennis Pluchinsky collection on terrorism and counterterrorism, 1956/201683
- Department of Living Sciences records, 1915/20034
- Dorothy Lee Baugher papers, 1936/2003, bulk 1975/19815
- Dudley and Rexrode Family Papers, 1873/20056
- Eldon Bowman collection of Bowman family papers, 1797/201914
- Emily Lewis Lee Papers, 1940/20067
- Emilyn Peterson Papers, 1929/2002, bulk 1929/19332
- Ernest M. Dickerman papers, 1904/200511