- Rick Boucher Papers, 1968/2017, bulk 1975/2011338
- The Road Company Records,, 1972/1998132
- Records of the Virginia Cooperative Extension, 1862/1997130
- Pamela Webb Architectural Collection,, 1950/2009123
- Dr. Richard Zallen Papers, 1940/2007116
- W. Dale Parker Papers, 1914/2006112
- Hidden History: The Black Experience in the Roanoke Valley Cassette Tapes and Transcripts, 1992107
- Virginia Academy of Science Records, 1920/2005102
- John T. Parsons Papers, 1910/200095
- Roanoke Appalachian Trail Club Records, 202592
- Robert E. Marshak Papers, 1933/199588
- M. Rupert Cutler Papers, 1930/2021, bulk 1962/202181
- William Hewitt Phillips Papers, 1918/200873
- James I. Robertson Jr. Papers, 1849/201160
- Alfred C. Payne Collection, 1917/200357