- Ancient Coins, 1956/19931
- Dr. Charles Ferguson McRae Collection, 1935/19931
- Dr. Herbert J. Sipe, Jr. Papers, 1927/20191
- Dr. James R. Leutze Papers, 1987/19901
- Dr. Ralph A. Rossum Papers, 1988/19921
- Dr. Walter Taylor Reveley II Papers, 1963/19931
- Elizabeth Carrington Eggleston Papers, 1899/19941
- Files of the Hampden-Sydney News & Information Office, 1980/19901
- Hampden-Sydney Library Records, 1930/20121
- Josiah Bunting III Papers, 1972/19981
- Log Cabin School Collection, 1966/20221
- Paul L. Grier Vertical Files, 1775/19881
- Records of the Merrill's Marauders Proud Descendants Association, 1944/20201
- Records of the Philanthropic, Union, and Union-Philanthropic Literary Societies, 1789/20071
- Richard McClintock Collection, 1960/20151