- S. Cole Bradley Papers, 1941/19942
- S. F. (Bill) Royall, Jr. papers, 1883/19793
- Saint Andrew's Society collection, 1861/199520
- Saleem A. Shah papers, 1952/199360
- Sallie Bennett Papers regarding World War I Flying Ace Louis Bennett, Jr., 1873/2009, bulk 1904/19262
- Sally H. Thomas papers, 1968/201015
- Sally Jane Brown, Artist, Collection, 1959/2023, bulk 2013/20203
- Sally Waldner Bould Stan Architectural Collection, 1940/199711
- Salvation Army Combined Corps Roll and Ledger, 1926/1980, bulk 1928/19692
- Sam Huff, West Virginia University and National Football League Football Player, Papers, 1930/2019, bulk 1955/20101
- Sam McColloch, Compiler, Three Manuscripts regarding Family History, Artists, and Fighter Pilot, 1904/20141
- Sam Sadler papers, 1960/200815
- Sam di Bonaventura papers, 1900/1998254
- Samuel F. Harsh Family, Genealogy, Photographs, and Artifacts, 1860/2011, bulk 1860/19101
- Samuel H. Chester papers, 18721