- Civitan and Civinette Clubs of Alexandria Collection (MS038), 1942/19782
- Curtin Family Papers (MS101), 1885/20004
- Delos H. Smith Collection (MS307), 1900/19501
- Edith Moore Sprouse Papers (MS313), 1960/20033
- Elanora Peake Zint Collection (MS345), 1924/20061
- Eleanor Lee Templeman Collection (MS061), 1810/199020
- Elrich W. Murphy Photograph Collection (MS415), 1940/19692
- Esther Holliday Green Collection (MS073), 1859/19827
- Ethelyn Cox Collection (MS287), 1956/198016
- Florence Davidson Collection (MS318), 1856/19833
- Glasgow Photo Collection (MS349), 1900/19791
- Helen Norris Cummings Papers (MS072), 1865/19492
- Historic Alexandria Foundation Records (MS070), 1949/19957
- Historic House Tours Collection (MS059), 1931/20172
- James E. Foley Railroad Collection (MS405), 1869/20024