- U.S. Forest Service, George Washington National Forest, Dry River District records, 1917/19944
- U.S. Selective Service System, West Virginia State Headquarters Records, 1956/19691
- UR's 175th Anniversary Collection, 1997/20081
- USS Hyades Shipmates' Reunion Collection, 1940/20121
- USS Vulcan (AR-5) Collection, 1898/198512
- USS West Virginia, Navy Uniform of Granville R. Williams, 1941/20011
- USS West Virginia, Scrapbook and Memorabilia, 1941/19911
- USS West Virginia, Scrapbook and Other Material of William Hand, 1934/1988, bulk 1934/19371
- Ulysses Grant Carter, Collector, Papers, Photographs, and Movie Films, 1928/19701
- Underwood Family Genealogy, 19641
- Union Baptist Church Records, Hopewell, Virginia, 1935/20071
- Union Carbide Corporation, Hawk's Nest Project, Papers, 1873/19663
- Unitarian Universalist Church of Norfolk Records, 1866/2011, bulk 1950/199094
- Unitarian Universalist Fellowship of the New River Valley Records, 1958/19873
- United Daughters of the Confederacy Records (MS155), 1919/19883