- U.S. Forest Service, George Washington National Forest, Dry River District records4
- U.S. Selective Service System, West Virginia State Headquarters Records1
- UR's 175th Anniversary Collection1
- USS Hyades Shipmates' Reunion Collection1
- USS Vulcan (AR-5) Collection11
- USS West Virginia, Navy Uniform of Granville R. Williams1
- USS West Virginia, Scrapbook and Memorabilia1
- USS West Virginia, Scrapbook and Other Material of William Hand1
- Ulysses Grant Carter, Collector, Papers, Photographs, and Movie Films1
- Union Baptist Church Records, Hopewell, Virginia1
- Union Carbide Corporation, Hawk's Nest Project, Papers3
- Unitarian Universalist Church of Norfolk Records85
- Unitarian Universalist Fellowship of the New River Valley Records2
- United Daughters of the Confederacy Records (MS155)3
- United Daughters of the Confederacy Williamsburg (Va.) records11