- A. S. Lara papers, 1856/18611
- Alumni Association Records, 1924/201620
- American Association of University Professors (AAUP). James Madison University Chapter records, 1944/19887
- American Association of University Women (AAUW) Records, Harrisonburg, Virginia Branch, 1929/20259
- Anthony-Seeger Campus School Records, 1956/19826
- Bethlehem Stone Church Records, 1844/201113
- Betty Brown Clemmer and Willis Clemmer papers, 1920/2015, bulk 1943/19493
- Betty Clougherty Miller papers, 1945/20002
- Betty Coe Cinquegrana papers, 1960/201411
- Blackley Family papers, 1830/202099
- Bowman Family Papers, 1765/19982
- Bradley and Brian Flota comic book collection, 1952/2008, bulk 1960/19992
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/199622
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19566
- Charles T. Smith photographs, 1880/2007, bulk 1990/19996