- T. Edward Temple Letters to Elmer T. Crowson, 1956/19831
- T. W. Hatcher Collection, 1919/1970, bulk 1920/19302
- Tamar Zuanna #116 Minute Book, 1951/19672
- Tate Thompson Brady Family papers, 1785/20057
- Tax reports of public service corporations from the State Corporation Commission,, 1895/20151
- Taylor family papers, 1894/19831
- Tazewell Family Papers, 1838/1978, bulk 1860/18701
- Terrill-Porterfield Families, Papers regarding the Civil War and Other Material, 1716/1994, bulk 1840/19201
- Terry Burton, Collector, Ogden House Collection, 1886/19971
- Terry L. Meyers papers, 1988/20102
- Thad W. Tate papers, 1949/20092
- Thaddeus Podratsky, Collector, Records Regarding the Socialist Party, 1911/2006, bulk 1911/19371
- The Alexandria Animal Welfare League Collection (MS075), 1946/19671
- The Center for Nursing Historical Inquiry collection, 1934/200121
- The Charles Baptie photograph collection, 1917/199560