- William Munford Tuck Papers, 1918/1968293
- Robert E. Marshak Papers, 1933/1995288
- Fries Textile Plant Records, 1900/1988282
- American Lung Association of Virginia (ALAV) collection, 1907/2004278
- Office of the President. Alvin Duke Chandler Records, 1936/1964, bulk 1951/1960276
- Harglo Glass Company Records, 1950/1970273
- Old Dominion University Photographic and Multimedia Collection, 1926/2007268
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974258
- Willis Guy Tetrick, Jr. Genealogy Research Papers, 1708/1997249
- James Wooddell, Compiler, Genealogy Research Papers, 1970/2000248
- Emory L. Kemp Papers regarding Industrial History, 1735/2021231
- Arena Stage records, 1949/2010228
- Papers of the Superintendent and Resident Director, 1850/1996222
- Arthur M. Squires Papers, 1888/1987, bulk 1940/1987221
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/1969214