- C. Harrison Mann, Jr. map collection, 1579/19611
- Charlotte Bowers Nelson papers, 1946/19611
- Civil War Collection, 1860/20121
- G. William Whitehurst Papers, 1925/19871
- H.E. Matheny, Collector and Compiler, Papers, 1956/19611
- James I. Robertson Jr. Papers, 1849/20111
- Judith Fenner Barnard Collection, 1914/19741
- Louis Watson Chappell (1890-1981), Folklorist, Research Papers, Sound Recordings, and Other Material, 1815/19801
- Mann-Hutchinson Family Correspondence, 1870/19691
- Pocahontas Mines Collection, 1883/19971
- Post Family letters, 1952/19571
- Smith-Riffe Collection, History and Genealogy of Lower New River Valley, 1930/19801
- Thornton Tayloe Perry, Collector, Papers, 1732/19651
- United Mine Workers of America, Health and Retirement Funds, Records, 1915/19891
- William and Anne Fleming Family papers, 1754/20001