- A. Edwin Kendrew Papers, 1930/19591
- A. H. Hand Papers, 1835/20092
- A. Willis Robertson Papers, 1921/1988, bulk 1946/19661,249
- Adam Empie Papers, 1811/2004, bulk 1811/18504
- Adele Blow Chatfield-Taylor family papers, 1899/197723
- African American Family Photographs, 1880/19604
- Albert E. Garrett, Jr. scrapbook, 1927/19741
- Albert E. Haak Scrapbook, 1947/19772
- Alexander Kallos Papers, 1939/19595
- Alfred R. Armstrong Papers, 1928/19761
- Allen-Kean-Laurence family letters, 1837/19602
- Althea Hunt Papers, 1926/196113
- Alumni Association Records, 1833/2014, bulk 1950/200567
- Alvin Duke Chandler Papers, 1896/1984, bulk 1950/196032
- American Association of University Professors, College of William and Mary Chapter Records, 1924/1979, bulk 1924/197921