- A. S. Lara papers, 1856/18611
- A.S. Hammack papers, 1864/19542
- Alumni Association Records, 1924/201617
- American Association of University Professors (AAUP). James Madison University Chapter records, 1944/19886
- American Association of University Women (AAUW) Records, Harrisonburg, Virginia Branch, 1929/20259
- Audrey Hawkins Rosenberger papers, 1950/19561
- Bethlehem Stone Church Records, 1844/201113
- Betty Brown Clemmer and Willis Clemmer papers, 1920/2015, bulk 1943/19493
- Betty Clougherty Miller papers, 1945/20002
- Blackley Family papers, 1830/2020103
- Bowman Family Papers, 1765/19982
- Bradley and Brian Flota comic book collection, 1952/2008, bulk 1960/19992
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/199631
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/195653
- Charles T. Smith photographs, 1880/2007, bulk 1990/19999