- Albert Moore Reese, Zoology Professor, Miscellaneous Items, 1900/19701
- Edward G. Carson Papers, 1924/2004, bulk 1970/20001
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/196935
- Ernest M. Dickerman papers, 1904/20051
- George Conoly Phillips Papers, 1909/20102
- Linwood H. Rose papers, 1949/2009, bulk 1985/20091
- Records of the Board of Visitors, 1908/20102
- Records of the Faculty, 1942/20141
- Records of the Office of the Vice President for Administration, Stuart K. Cassell, 1945/19751
- Records of the Virginia Cooperative Extension, 1862/19976
- Records of the Virginia Tech Board of Visitors, 1873/20098
- Records of the Virginia Tech University Libraries, 1925/20061
- Robert James Sullivan Jr. papers, 1920/20131
- Ruth and Lowell Toliver Collection of Newman Family Papers, 1875/20053
- Southside Garden Club Records, 1914/20091