- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974288
- Carl A. "Pappy" Fehr papers, 1907/2012, bulk 1945/1974259
- Mount Vernon Black and White Film Collection, 1933/2005247
- Willis Guy Tetrick, Jr. Genealogy Research Papers, 1708/1997220
- American Lung Association of Virginia (ALAV) collection, 1907/2004156
- Harry Flood Byrd, Sr. Papers
1911-1965125
- Bailey-Law Collection, 1825/1971101
- W. Graham Claytor Papers, 1912/196499
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Pocahontas Mines Collection, 1883/199778
- Smokeless Fuel Co. Records, 1935/195775
- Adele Goodman Clark papers, 1849/197869
- Cocke and Related Family Papers, ca.1773-199263
- United Mine Workers of America, Health and Retirement Funds, Records, 1915/198948
- WLUR Recordings and Broadcasts, 1938/201047