- A.J. Morrison Collection, 1754/19751
- Brock Family Certificate Collection, 1870/19541
- Chemistry Department Purchase Ledger, 1946/19621
- Dr. Charles Ferguson McRae Collection, 1935/19931
- Dr. Herbert J. Sipe, Jr. Papers, 1927/20191
- Elizabeth Carrington Eggleston Papers, 1899/19941
- Hampden-Sydney Diploma Collection, 1775/19741
- Hampden-Sydney Library Records, 1930/20121
- J. D. Eggleston Papers, 1750/19521
- Paul L. Grier Vertical Files, 1775/19881
- Prince Edward County Integration Collection, 1943/19751
- Records of Phi Beta Kappa, 1930/19521
- Records of the Merrill's Marauders Proud Descendants Association, 1944/20201
- Records of the Philanthropic, Union, and Union-Philanthropic Literary Societies, 1789/20071
- Samuel Vaughan Wilson Papers, 1945/20171