- A. S. Lara papers, 1856/18611
- Alumni Association Records, 1924/20166
- American Association of University Professors (AAUP). James Madison University Chapter records, 1944/19883
- American Association of University Women (AAUW) Records, Harrisonburg, Virginia Branch, 1929/20253
- Betty Brown Clemmer and Willis Clemmer papers, 1920/2015, bulk 1943/194911
- Betty Clougherty Miller papers, 1945/20001
- Blackley Family papers, 1830/202095
- Bowman Family Papers, 1765/19981
- Bridgewater Women's Voter Roll, 1920/19511
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/199625
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19562
- Charles T. Smith photographs, 1880/2007, bulk 1990/19995
- Chesapeake Western Railway Company Records, 1916/198219
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20004
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19281