- Thomas L. Williams collection, 1940/19901,315
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/19741,173
- Siler Family Papers, 1848/19681,160
- Writers' Program in West Virginia Records, 1850/1942, bulk 1935/19421,133
- O.W. Riegel Papers, 1900/1992853
- Long/Trail Southeastern West Virginia Historical Records, 1870/2025654
- Gregory A. Prince Mormon Studies Collection, 1813/2020432
- Fries Textile Plant Records, 1900/1988354
- W. Jett Lauck papers, 1900/1952351
- The University of Virginia Anatomy Laboratory Lantern Slides collection, 1920/1965325
- Willis Guy Tetrick, Jr. Genealogy Research Papers, 1708/1997292
- Papers of the Superintendent and Resident Director, 1850/1996234
- American Public Transportation Association records, 1898/1999233
- Farrier Family Papers, 1894/1972231
- Emory L. Kemp Papers regarding Industrial History, 1735/2021221