- S. Allen Rubin Letters, 1941/19432
- S. Cole Bradley Papers, 1941/19942
- S. Corder Musgrave Papers, 1891/19661
- S. F. (Bill) Royall, Jr. papers, 1883/19792
- S. George Company Records, 1900/19751
- S. Louise Seymour Scrapbooks, 1939/19433
- S. Maria Elliott Family Collection, 1826/19422
- S. Vernon McCasland papers, 1928/19542
- Saint Andrew's Society collection, 1861/199510
- Sallie Bennett Papers regarding World War I Flying Ace Louis Bennett, Jr., 1873/2009, bulk 1904/19266
- Sallie and Stephen Fisher Travel Diaries, 1940/19502
- Sally Waldner Bould Stan Architectural Collection, 1940/19971
- Salvation Army Combined Corps Roll and Ledger, 1926/1980, bulk 1928/19692
- Sam Bowman Papers, 1848/19673
- Sam Huff, West Virginia University and National Football League Football Player, Papers, 1930/2019, bulk 1955/20101