- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974879
- The University of Virginia Anatomy Laboratory Lantern Slides collection, 1920/1965323
- Willis Guy Tetrick, Jr. Genealogy Research Papers, 1708/1997210
- Bailey-Law Collection, 1825/1971161
- Carl A. "Pappy" Fehr papers, 1907/2012, bulk 1945/1974125
- Harry Flood Byrd, Sr. Papers
1911-1965108
- Mount Vernon Black and White Film Collection, 1933/2005105
- Topographic Maps, 1891/1989, bulk 1900/198085
- American Lung Association of Virginia (ALAV) collection, 1907/200481
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190080
- Wheeling Steel Radio Program Sound Recordings and Records, 1937/2010, bulk 1937/194472
- Adele Goodman Clark papers, 1849/197865
- Cocke and Related Family Papers,
ca.1773-199260
- W. Graham Claytor Papers, 1912/196460
- Chapman J. French Papers, 1903/195756