- C. S. Buchanan Augusta Military Academy scrapbook, 1918/1944, bulk 1918/19192
- Carrie Bishop Scrapbook, 1914/19183
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/199629
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19562
- Charles T. Smith photographs, 1880/2007, bulk 1990/19995
- Chesapeake Western Railway Company Records, 1916/198231
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/200010
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19284
- Cleveland Family Papers, 1880/19585
- Cross Keys Precinct voting records, 1902/19606
- Croushorn Family Rockingham Cooperative Farm Bureau Papers, 1932/19582
- Daisy Bacon Papers, 1857/198621
- Davis & Associates architectural drawings, 1925/19864
- Davis, Kline, and Hutton Family papers, 1816/19778
- Debating Club Records, 1928/19403