- T. W. Hatcher Collection, 1919/1970, bulk 1920/19301
- Tate Thompson Brady Family papers, 1785/20057
- Tau Kappa Alpha Records, 1928/19331
- Tax reports of public service corporations from the State Corporation Commission,, 1895/20151
- Taylor County Justice Docket, 1935/19371
- Taylor Family Papers, 1903/19579
- Taylor collection of Lewis family papers, 1700/19501
- Taylor family papers, 1894/19831
- Tazewell Family Papers, 1838/1978, bulk 1860/18701
- Telluric Company, Investment Company Record Book, 1891/19541
- Tennessee Williams Collection
1935-[1975]2
- Terrill-Porterfield Families, Papers regarding the Civil War and Other Material, 1716/1994, bulk 1840/19201
- Terry Burton, Collector, Ogden House Collection, 1886/19971
- Thaddeus Podratsky, Collector, Records Regarding the Socialist Party, 1911/2006, bulk 1911/19371
- The Betrayal relief prints, 1920/19501