- Catlett Family Papers, 1850/1933, bulk 1901/19297
- Charles Grattan Price Jr. and Don W. Thomas collection on the Chesapeake Western Railway, 1872/199618
- Charles Grattan Price Jr. collection on Tweetsie and the Shenandoah Central Railroad, 1916/1997, bulk 1948/19562
- Charles T. Smith photographs, 1880/2007, bulk 1990/199915
- Chesapeake Western Railway Company Records, 1916/19822
- Christine Hoepfner Collection on the Shenandoah National Park, 1911/20005
- Civil War Miscellaneous Collection, 1860/2005, bulk 1862/19287
- Class of 1913 Reunion Book, 1914/19352
- Cleveland Family Papers, 1880/19585
- Cross Keys Precinct voting records, 1902/19609
- Daisy Bacon Papers, 1857/198619
- Davis & Associates architectural drawings, 1925/19863
- Davis, Kline, and Hutton Family papers, 1816/197710
- Delphine Hurst Parsons papers, 1923/1976, bulk 1923/193113
- Department of Living Sciences records, 1915/20034