- Siler Family Papers, 1848/19681,154
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974622
- Long/Trail Southeastern West Virginia Historical Records, 1870/2025584
- Gregory A. Prince Mormon Studies Collection, 1813/2020415
- Edward L. Stone/Borderland Coal Company Papers
1895-1937325
- The University of Virginia Anatomy Laboratory Lantern Slides collection, 1920/1965325
- W. Jett Lauck papers, 1900/1952324
- Farrier Family Papers, 1894/1972267
- Duke family law firm papers, 1820/1959262
- G. Walter Mapp Papers, 1873/1941257
- duPont family papers, 1767/1982245
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/1969232
- Samuel Davis Stokes Papers, 1915/1925228
- Bailey-Law Collection, 1825/1971216
- West Virginia University, President's Office, Records, 1864/1989206