- C. Harrison Mann, Jr. map collection, 1579/19611
- Cabinet Photograph of Unknown Mountain and Valley Scene, 1880/19201
- Civil War Collection, 1860/20121
- Dillon Family Papers, 1805/19441
- Goshorn Family Papers, 1827/19261
- Haymond-Fleming Law Firm Papers, 1760/19361
- J.C. Sanders, Collector, Papers, 1700/19501
- James I. Robertson Jr. Papers, 1849/20111
- Judith Fenner Barnard Collection, 1914/19741
- Lewis Family Papers, 1825/19361
- Louis Watson Chappell (1890-1981), Folklorist, Research Papers, Sound Recordings, and Other Material, 1815/19801
- Mann-Hutchinson Family Correspondence, 1870/19691
- Minnie Kendall Lowther Papers, 1907/19451
- Oren F. Morton (1857-1926) Papers, 1799/19261
- Oscar Doane Lambert, Historian, Papers regarding Historical Research, 1770/19291