- Alexander Farish Robertson Papers, 1867/19316
- Alfred C. Payne Collection, 1917/20031
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records, 1890/20221
- Bailey-Law Collection, 1825/197111
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19981
- Black, Kent, and Apperson Family Papers, 1779/19845
- Blacksburg Baptist Church Records, 1894/20074
- Charles Willis Cassell Family Papers, 1883/195011
- Dickson Family Papers, 1769/19241
- Dillard-Larkin Family Papers, 1809/19551
- Earle D. Gregory Collection, 1915/19971
- Elden E. Billings Collection, 1862/19912
- Eleanore Pettersen Architectural Collection, 1915/2003, bulk 1950/20002
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19695
- Henry C. Wysor Family Papers, 1869/19181