- Alexander Farish Robertson Papers, 1867/19316
- Bailey-Law Collection, 1825/19715
- Bell, Kent, Cloyd, Withrow Family Collection, 1780/19981
- Black, Kent, and Apperson Family Papers, 1779/19848
- Blacksburg Baptist Church Records, 1894/20076
- Charles Willis Cassell Family Papers, 1883/195011
- Dickson Family Papers, 1769/19242
- Dillard-Larkin Family Papers, 1809/19551
- Elden E. Billings Collection, 1862/19912
- Episcopal Diocese of Southwestern Virginia Records, 1866/2004, bulk 1919/19692
- Henry C. Wysor Family Papers, 1869/19184
- Henry H. Hill Collection, 1893/19631
- J. Hoge Tyler Family Collection, 1802/195624
- John Barnes Performing Arts Collection, 1890/1983, bulk 1940/19691
- John D. Clark Papers, 1923/19881