- A. J. Davis Family Collection, 1874/2007, bulk 1874/19071
- Adam Finch Collection, 1891/19331
- Adam T. Finch Papers, 1895/19261
- Adin B. Underwood Papers, 1861/19261
- Albert L. Sturm Papers, 1904/19881
- Alexander Farish Robertson Papers, 1867/19311
- Alexander W. Brown Diaries, 1904/19211
- Alleghany Chapter, National Society of the Daughters of the American Revolution Records, 1890/20221
- Ambrose L. Snavely Papers, 1903/19521
- American Locomotive Company/Baldwin Locomotive Works Illustrations, 1900/19251
- Ann A. Hertzler Collection, 1863/2013, bulk 1974/20001
- Anna Burton Ellett Collection, 1751/19321
- Anne H. Price Yates Papers, 1904/1985, bulk 1975/19851
- Anne Price Yates Papers II, 1898/20051
- Annie M. Hale Sheet Music Collection, 1892/19871