- Abraham Lincoln Collection, 1860/19651
- Ackerly Family Papers8
- Administration records collection, 1776/197616
- Advertisement Trade Card for "Quignon-Rombach", 1880/19201
- African and African American photograph collection, 1850/19451
- Alan R. Shirkey photograph collection, 1877/19175
- Alexander Lockhart Nelson papers, 1848/19021
- Alexander Sterrett Paxton Papers, 1858/1959, bulk 1861/18652
- Alexander, Fultz, and Willson Families Collection, 1770/19701
- Almanac collection, 1850/19092
- Alphin Family Photographs, 1870/19301
- Anderson Family papers, 1755/195813
- Anderson Family photograph albums, 1899/19003
- Ann Smith Academy Papers, 1807/19101
- Anne McClung Collection, 1844/19663