- Papers of the Low Moor Iron Company
1873-1927146
- Papers of Mark Twain
1862-1946, bulk 1872-1910119
- Tyler Family Papers, Group D, 1939/195194
- Edward "Teddy" Bolton Tucker Papers, 1760/2007, bulk 1800/190079
- Historical Photograph Collection, 1850/201072
- Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/197467
- Duke Family Papers
1764-198363
- Snyder Family papers, 1850/190146
- Monongalia County (W. Va.) Court Records and Miscellaneous Papers, 1774/195442
- W.E. Bibb Papers
1830-194036
- Bailey-Law Collection, 1825/197132
- Map Collection, 1629/199132
- Roy Bird Cook (1886-1961), Collector, Papers, 1679/1984, bulk 1840/196024
- Hampden-Sydney College Photograph Collection, 177523
- Cocke and Related Family Papers, ca.1773-199221